好消息！【medical-news】抗体引爆MRSA死亡

Divide and conquer no more (Image: David Scharf/Getty)

不再分裂与攻占


MRSA is a highly antibiotic-resistant form of the bacteria Staphylococcus Aureus which kills about 20,000 people in the US alone each year. Although a small number of antibiotics work against MRSA, the bacteria is constantly evolving resistant strains.


MRSA为金黄色葡萄球菌的高耐抗生素型，每年仅在美国就导致二万人死亡。虽然有一小部分的抗生素能够对抗MRSA，但该细菌时刻进化、耐药菌株不断出现。


Edward Schwartz and colleagues at the University of Rochester Medical Center in New York have identified an antibody which targets a protein called glucosaminidase (GMD) deep within MRSA that has a key role in breaking down the cell wall, enabling the bacterium to divide.


纽约罗彻斯特大学医学中心的Edward Schwartz 及其同事已确认一种其靶标为MRSA内部氨基萄糖苷酶（GMD）的抗体。GMD在击破细胞壁、允许细菌分裂方面扮演着关键角色。


What's more, the protein is genetically identical in all strains, so a vaccine that targets GMD could potentially be universal.


更进一步的是，所有菌株内该蛋白在遗传水平上都是一样的，这样靶标为GMD的疫苗就具有通用潜力。


The team grew MRSA in culture alongside the new antibody. Bacteria exposed to the antibody either fused into long chains or exploded, significantly inhibiting bacterial growth.


研究小组将MRSA置于含有该新抗体的培养基中。暴露于该抗体的细菌要么融合成长链、要么爆炸，从而极大地抑制了细菌的生长。


The research was presented on Saturday at the Orthopaedic Research Society meeting in Long Beach, California.


本研究已于周六提交于在加州长滩召开的美国骨科学会（Orthopaedic Research Society, ORS）会议。

Docofsoul 译于2011年1月18日星期二


内容来源：http://news.dxy.cn/bbs/topic/19253283

作者：Docofsoul